OCSTAMP

Across TCGA pan-cancer cohorts, OCSTAMP RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of OCSTAMP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OCSTAMP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OCSTAMP is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where OCSTAMP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OCSTAMP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	+0.170	<.001	9	view →
KIRC	All	All	−0.024	<.001	6	view →
KICH	All	II,III,IV	−0.029	.012	4	view →
KIRP	Female	II,III,IV	−0.064	.003	3	view →
STAD	All	II,III,IV	+0.043	.016	3	view →
LUSC	All	All	+0.096	.001	2	view →
LUAD	All	IV	−0.065	.005	2	view →
COAD	All	All	+0.056	.012	2	view →
PRAD	All	All	+0.017	.013	2	view →
LUAD	Female	II,III,IV	+0.098	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

OCSTAMP–THCA

Open the THCA breakdown →