OCSTAMP

Across TCGA cell cohorts, OCSTAMP mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OCSTAMP-associated genes across cancer lineages are KRTAP2-4, OOSP4A, and CACNG5. Each is linked with OCSTAMP in more than 1 cancer types. Because this analysis shows association rather than direction, both OCSTAMP-to-partner and partner-to-OCSTAMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP2-4 grouped by OCSTAMP-low versus OCSTAMP-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OCSTAMP→partner) and Y-score (partner→OCSTAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP2-4 →	+0.122	+4.930	<.001	.008	3	1
SOFT_TISSUE	OOSP4A →	+0.067	+4.930	<.001	.008	3	1
BREAST	CACNG5 →	+0.186	+4.421	<.001	.004	3	1
LARGE_INTESTINE	DAZ4 →	+0.141	+3.562	.002	.002	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	RBMY1J →	+0.005	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KRTAP2-4 by OCSTAMP expression — SOFT_TISSUE

Explore this box plot interactively →