OCRL

Across TCGA cell cohorts, OCRL mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OCRL-associated genes across cancer lineages are OTOP1, IDI2, and NXPE4. Each is linked with OCRL in more than 1 cancer types. Because this analysis shows association rather than direction, both OCRL-to-partner and partner-to-OCRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOP1 grouped by OCRL-low versus OCRL-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OCRL→partner) and Y-score (partner→OCRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOP1 →	+0.210	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	IDI2 →	+0.032	+4.299	<.001	.001	3	1
BLOOD_Leukemia	NXPE4 →	+0.020	+4.276	<.001	.007	3	1
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.017	+3.453	.003	.009	3	1
LARGE_INTESTINE	OR52H1 →	+0.032	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OTOP1 by OCRL expression — URINARY_TRACT

Explore this box plot interactively →