OCM

Across TCGA patient cohorts, OCM mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OCM-associated genes across cancer lineages are RNA5SP408, PGBD4P2, and TMEM225. Each is linked with OCM in more than 1 cancer types. Because this analysis shows association rather than direction, both OCM-to-partner and partner-to-OCM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP408 grouped by OCM-low versus OCM-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OCM→partner) and Y-score (partner→OCM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP408 →	+0.308	+7.930	<.001	.008	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	1
READ	RNU6-1274P →	+0.547	+5.925	<.001	.002	3	1
READ	FOXO1B →	+0.146	+5.039	<.001	.008	3	1
READ	OR6K5P →	+0.057	+6.257	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

RNA5SP408 by OCM expression — LUAD

Explore this box plot interactively →