OCM

Across TCGA pan-cancer cohorts, OCM RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of OCM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where OCM RNA is repressed in tumor relative to normal tissue. In most cancer types OCM is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where OCM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OCM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.193	<.001	10	view →
LIHC	All	All	+0.078	<.001	7	view →
THCA	Male	All	−0.345	<.001	5	view →
BRCA	All	All	−0.229	<.001	4	view →
CHOL	All	All	+0.361	.006	2	view →
KIRP	All	All	+0.222	.015	2	view →
LUAD	All	All	+0.123	.027	2	view →
ESCA	Female	All	−0.296	.021	1	view →
LUSC	Male	III,IV	−0.222	.048	1	view →
KIRC	All	All	+0.057	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

OCM–KICH

Open the KICH breakdown →