OCEL1

Across TCGA cell cohorts, OCEL1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OCEL1-associated genes across cancer lineages are FCN2, ITGAD, and ACSM6. Each is linked with OCEL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OCEL1-to-partner and partner-to-OCEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by OCEL1-low versus OCEL1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OCEL1→partner) and Y-score (partner→OCEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FCN2 →	+0.060	+6.022	<.001	.001	3	1
LARGE_INTESTINE	ITGAD →	+0.014	+4.510	<.001	.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.031	+4.584	<.001	<.001	3	1
LARGE_INTESTINE	IFIT1B →	+0.033	+3.823	.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FCN2 by OCEL1 expression — SKIN

Explore this box plot interactively →