OCA2

Across TCGA cell cohorts, OCA2 mutation is significantly associated with the RNA expression of many other genes, with 172 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OCA2-associated genes across cancer lineages are C8orf74, WFDC10A, and H4C6. Each is linked with OCA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OCA2-to-partner and partner-to-OCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8orf74 grouped by OCA2-low versus OCA2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OCA2→partner) and Y-score (partner→OCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C8orf74 →	+0.029	+5.369	<.001	.004	3	2
CNS	WFDC10A →	+0.063	+4.315	.007	.006	3	2
LUNG_NSCLC_LUAD	H4C6 →	+0.155	+3.212	.001	<.001	3	2
LARGE_INTESTINE	GPR63 →	+0.935	+3.169	<.001	.009	3	2
SOFT_TISSUE	LRRC52 →	+0.022	+4.930	<.001	.008	3	1
CNS	G6PC2 →	+0.019	+4.472	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 172 associations by consensus.

C8orf74 by OCA2 expression — SOFT_TISSUE

Explore this box plot interactively →