OBSL1

Across TCGA cell cohorts, OBSL1 mutation is significantly associated with the RNA expression of many other genes, with 918 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OBSL1-associated genes across cancer lineages are ZNF705A, COX6A2, and KRTAP5-4. Each is linked with OBSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OBSL1-to-partner and partner-to-OBSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF705A grouped by OBSL1-low versus OBSL1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBSL1→partner) and Y-score (partner→OBSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF705A →	+0.047	+3.129	<.001	.003	3	2
CNS	COX6A2 →	+0.165	+3.459	<.001	.006	3	2
SKIN	KRTAP5-4 →	+0.041	+3.240	.001	.004	3	2
OVARY	SERPINA2 →	+0.155	+3.807	<.001	.003	3	2
BLOOD_Leukemia	CALHM4 →	+0.015	+3.099	<.001	.001	3	2
BLOOD_Leukemia	MC5R →	+0.623	+2.908	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 918 associations by consensus.

ZNF705A by OBSL1 expression — LUNG_SCLC

Explore this box plot interactively →