OBSCN

Across TCGA cell cohorts, OBSCN mutation is significantly associated with the RNA expression of many other genes, with 1,686 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OBSCN-associated genes across cancer lineages are SDE2, HIBADH, and FHL3. Each is linked with OBSCN in more than 3 cancer types. Because this analysis shows association rather than direction, both OBSCN-to-partner and partner-to-OBSCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDE2 grouped by OBSCN-low versus OBSCN-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBSCN→partner) and Y-score (partner→OBSCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SDE2 →	+0.529	+1.722	.001	.007	3	4
LUNG_NSCLC_LUAD	HIBADH →	-0.503	-1.355	.001	.004	3	4
BLOOD_Leukemia	FHL3 →	-0.763	-1.362	.009	.009	3	4
LARGE_INTESTINE	ATP5F1B →	+0.399	+0.879	.001	.006	3	4
LARGE_INTESTINE	PARS2 →	+0.264	+1.169	.008	.005	3	4
LARGE_INTESTINE	B2M →	-1.472	-1.126	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,686 associations by consensus.

SDE2 by OBSCN expression — STOMACH

Explore this box plot interactively →