OBP2A

Across TCGA patient cohorts, OBP2A mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OBP2A-associated genes across cancer lineages are p38-MAPK, PCNA, and PKC-b-II_pS660. Each is linked with OBP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both OBP2A-to-partner and partner-to-OBP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK grouped by OBP2A-low versus OBP2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBP2A→partner) and Y-score (partner→OBP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK →	-0.181	-2.979	.035	.036	3	1
UCEC	PCNA →	+0.261	+3.169	.021	.019	3	1
UCEC	PKC-b-II_pS660 →	-0.350	-3.321	.015	.010	3	1
UCEC	MEK1 →	+0.444	+3.169	.020	.019	2	1
UCEC	mTOR_pS2448 →	-0.189	-3.321	.015	.010	2	1
UCEC	ATM →	-0.806	-3.000	<.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

p38-MAPK by OBP2A expression — UCEC

Explore this box plot interactively →