OBI1

Across TCGA cell cohorts, OBI1 mutation is significantly associated with the RNA expression of many other genes, with 482 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OBI1-associated genes across cancer lineages are NOBOX, OR6V1, and CSN1S1. Each is linked with OBI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OBI1-to-partner and partner-to-OBI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOBOX grouped by OBI1-low versus OBI1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBI1→partner) and Y-score (partner→OBI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NOBOX →	+0.032	+5.321	<.001	.005	3	2
LARGE_INTESTINE	OR6V1 →	+0.018	+2.204	<.001	.005	3	2
LUNG_NSCLC_LUAD	CSN1S1 →	+0.041	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	C10orf71 →	+0.029	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR2G6 →	+0.013	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	C8B →	+0.040	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 482 associations by consensus.

NOBOX by OBI1 expression — CNS

Explore this box plot interactively →