OBI1-AS1

Across TCGA pan-cancer cohorts, OBI1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated OBI1-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher OBI1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OBI1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

UCEC, UVM, and UCS are the cancer types where OBI1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.898	0.946	.005	82	view →
UVM	DFS	Tertile	II,III,IV	0.784	0.383	.005	61	view →
UCS	OS	Tertile	II,III,IV	0.703	0.243	.005	58	view →
LGG	DFS	Median	All	0.813	0.661	<.001	54	view →
KIRP	DFS	Median	All	0.521	0.693	.004	27	view →
OV	DFS	Median	IV	0.302	0.583	<.001	22	view →
COAD	OS	Tertile	All	0.805	0.911	.013	17	view →
ACC	DFS	Quartile	II,III,IV	0.304	0.621	.012	16	view →
MESO	DFS	Tertile	All	0.400	0.654	.034	12	view →
STAD	DFS	Tertile	III,IV	0.392	0.546	.024	9	view →
READ	DFS	Median	IV	0.372	0.718	.015	9	view →
DLBC	DFS	Quartile	All	0.311	0.787	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

OBI1-AS1–UCEC (OS)

Open the UCEC breakdown →