OBI1-AS1

Across TCGA pan-cancer cohorts, OBI1-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of OBI1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OBI1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OBI1-AS1 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

KIRC, BLCA, and STAD are the cancer types where OBI1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OBI1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.062	<.001	11	view →
BLCA	All	III,IV	+0.032	.001	8	view →
STAD	Male	All	+0.035	<.001	6	view →
COAD	Male	II,III,IV	+0.038	.006	5	view →
LUAD	All	III,IV	−0.042	<.001	4	view →
KICH	All	All	−0.034	<.001	4	view →
HNSC	All	II,III,IV	+0.009	.009	4	view →
BRCA	All	IV	+0.040	.029	2	view →
LIHC	All	All	+0.008	.009	2	view →
LUSC	Female	All	−0.026	.022	1	view →
KIRP	All	II,III,IV	+0.021	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

OBI1-AS1–KIRC

Open the KIRC breakdown →