OAZ3

Across TCGA patient cohorts, OAZ3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OAZ3-associated genes across cancer lineages are ER-alpha_pS118, p62 Lck ligand, and HER3. Each is linked with OAZ3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OAZ3-to-partner and partner-to-OAZ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by OAZ3-low versus OAZ3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAZ3→partner) and Y-score (partner→OAZ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	-0.409	-3.169	.038	.020	3	1
UCEC	p62 Lck ligand →	+0.771	+3.009	<.001	.019	3	1
SKCM	HER3 →	+0.544	+2.824	.029	.036	3	1
UCEC	IGFBP2 →	-0.849	-3.169	.017	.020	2	1
UCEC	Caspase-7-cleavedD198 →	+1.194	+3.169	<.001	.020	1	1
UCEC	4E-BP1 →	+0.352	+3.169	.017	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ER-alpha_pS118 by OAZ3 expression — UCEC

Explore this box plot interactively →