OAZ2

Across TCGA patient cohorts, OAZ2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OAZ2-associated genes across cancer lineages are ERK2, Lck, and MSH2. Each is linked with OAZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OAZ2-to-partner and partner-to-OAZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by OAZ2-low versus OAZ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAZ2→partner) and Y-score (partner→OAZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.216	+2.999	.020	.035	3	1
UCEC	Lck →	+0.207	+2.459	.033	.020	3	1
UCEC	MSH2 →	-0.263	-3.160	.018	.019	3	1
UCEC	Notch1 →	+0.139	+3.009	.041	.019	3	1
UCEC	p62 Lck ligand →	+0.492	+2.179	.001	.034	3	1
UCEC	STAT5a →	+0.510	+2.459	.008	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ERK2 by OAZ2 expression — UCEC

Explore this box plot interactively →