OAT

Across TCGA pan-cancer cohorts, OAT mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated OAT data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher OAT mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OAT expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

CCRCC, GBM, and COAD are the cancer types where OAT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.508	0.876	.001	31	view →
GBM	DFS	Median	All	0.822	0.617	.001	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LSCC	DFS	Median	All	0.567	0.937	.006	5	view →
PDAC	OS	Quartile	All	0.751	0.953	.023	5	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	5	view →
HNSC	DFS	Tertile	All	1.000	0.946	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OAT–CCRCC (DFS)

Open the CCRCC breakdown →