OAT

Across TCGA pan-cancer cohorts, OAT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of OAT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OAT RNA is repressed in tumor relative to normal tissue. In most cancer types OAT is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where OAT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OAT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.071	<.001	11	view →
THCA	Male	III,IV	−1.337	<.001	10	view →
KIRP	Male	All	−1.289	<.001	9	view →
LUAD	Male	All	+1.009	<.001	7	view →
BLCA	All	All	−1.068	.011	6	view →
KICH	Female	All	−0.869	<.001	5	view →
LUSC	Male	All	+0.477	<.001	5	view →
HNSC	Male	II,III,IV	−0.678	<.001	4	view →
LIHC	All	All	−1.089	.001	3	view →
PRAD	All	All	−0.963	<.001	2	view →
UCEC	All	All	−0.710	.010	2	view →
COAD	Female	IV	−1.540	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

OAT–KIRC

Open the KIRC breakdown →