OAT

Across TCGA patient cohorts, OAT mutation is significantly associated with the RNA expression of many other genes, with 2,737 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OAT-associated genes across cancer lineages are KRTAP19-5, RNU6-909P, and MFSD14C. Each is linked with OAT in more than 1 cancer types. Because this analysis shows association rather than direction, both OAT-to-partner and partner-to-OAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP19-5 grouped by OAT-low versus OAT-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAT→partner) and Y-score (partner→OAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KRTAP19-5 →	+0.468	+5.798	<.001	.003	3	2
LUAD	RNU6-909P →	+2.297	+4.990	<.001	.009	3	2
UCEC	MFSD14C →	+0.759	+3.202	<.001	<.001	3	2
UCEC	AKR1B1P3 →	+0.240	+2.545	.001	.001	3	2
UCEC	RNU4-65P →	+0.139	+2.951	<.001	.007	3	2
UCEC	TMEM9B-AS1 →	+0.529	+2.010	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,737 associations by consensus.

KRTAP19-5 by OAT expression — LUAD

Explore this box plot interactively →