OAT

Across TCGA patient cohorts, OAT mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OAT-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and p62 Lck ligand. Each is linked with OAT in more than 1 cancer types. Because this analysis shows association rather than direction, both OAT-to-partner and partner-to-OAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by OAT-low versus OAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAT→partner) and Y-score (partner→OAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.189	-1.986	.012	.032	3	1
UCEC	Notch1 →	+0.196	+2.000	.002	.032	3	1
UCEC	p62 Lck ligand →	+0.347	+2.700	.018	.006	3	1
UCEC	Rad50 →	-0.267	-2.000	.014	.032	3	1
UCEC	S6_pS235_S236 →	+0.408	+2.700	.036	.006	3	1
UCEC	S6_pS240_S244 →	+0.461	+2.700	.011	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK_pT183_Y185 by OAT expression — UCEC

Explore this box plot interactively →