OAT

Across TCGA cell cohorts, OAT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,235 significant associations in total. BONE shows the largest number of these associations.

The most reproducible OAT-associated GO terms across cancer lineages are L-proline biosynthetic process, L-proline metabolic process, and L-arginine catabolic process. Each is linked with OAT in more than 14 cancer types. Because this analysis shows association rather than direction, both OAT-to-partner and partner-to-OAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-proline biosynthetic process grouped by OAT-low versus OAT-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OAT→partner) and Y-score (partner→OAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	L-proline biosynthetic process →	+0.191	+2.767	<.001	<.001	3	15
BLOOD_Lymphoma	L-proline metabolic process →	+0.159	+1.495	<.001	<.001	3	10
BLOOD_Leukemia	L-arginine catabolic process →	+0.670	+2.253	<.001	<.001	3	9
BONE	Chaperone-mediated autophagy →	+0.174	+1.382	<.001	<.001	3	8
BONE	Phospholipid dephosphorylation →	+0.077	+2.095	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	One-carbon metabolic process →	+0.094	+0.948	.005	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,235 associations by consensus.

L-proline biosynthetic process by OAT expression — BLOOD_Leukemia

Explore this box plot interactively →