OASL

Across TCGA patient cohorts, OASL mutation is significantly associated with the RNA expression of many other genes, with 1,801 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OASL-associated genes across cancer lineages are RNA5SP411, SNORD114-18, and SNORD114-22. Each is linked with OASL in more than 2 cancer types. Because this analysis shows association rather than direction, both OASL-to-partner and partner-to-OASL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by OASL-low versus OASL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OASL→partner) and Y-score (partner→OASL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.285	+2.256	<.001	<.001	3	3
LUAD	SNORD114-18 →	+1.489	+6.739	<.001	<.001	3	3
LUAD	SNORD114-22 →	+1.219	+7.924	<.001	<.001	3	3
LUAD	RNU7-180P →	+2.198	+5.343	<.001	.006	3	3
LUSC	RPL17P19 →	+0.120	+3.811	<.001	.002	3	3
LUSC	RNA5SP408 →	+0.505	+5.333	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,801 associations by consensus.

RNA5SP411 by OASL expression — UCEC

Explore this box plot interactively →