OASL

Across TCGA pan-cancer cohorts, OASL RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated OASL data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher OASL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OASL expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

UVM, SKCM, and ACC are the cancer types where OASL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.427	0.731	<.001	104	view →
SKCM	OS	Median	All	0.407	0.272	<.001	93	view →
ACC	OS	Quartile	II,III,IV	0.704	1.000	<.001	75	view →
KIRC	OS	Median	All	0.757	0.853	<.001	72	view →
PAAD	OS	Median	All	0.289	0.489	<.001	55	view →
LGG	OS	Median	All	0.358	0.526	<.001	50	view →
SCLC	DFS	Median	II,III,IV	0.751	0.433	.001	37	view →
CESC	DFS	Tertile	All	0.879	0.775	.009	34	view →
UCEC	DFS	Tertile	All	0.781	0.873	.007	32	view →
LAML	DFS	Tertile	All	0.306	0.726	<.001	30	view →
STAD	DFS	Median	All	0.541	0.717	.001	27	view →
READ	DFS	Median	II,III,IV	0.877	0.710	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

OASL–UVM (DFS)

Open the UVM breakdown →