OASL

Across TCGA cell cohorts, OASL mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible OASL-associated genes across cancer lineages are EVX2, CCDC60, and SPINK8. Each is linked with OASL in more than 1 cancer types. Because this analysis shows association rather than direction, both OASL-to-partner and partner-to-OASL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EVX2 grouped by OASL-low versus OASL-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OASL→partner) and Y-score (partner→OASL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EVX2 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CCDC60 →	+0.033	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	SPINK8 →	+0.438	+5.228	<.001	.005	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.977	<.001	.007	3	1
SKIN	OR6B3 →	+0.136	+6.022	<.001	.001	3	1
CNS	SEMG1 →	+0.024	+4.472	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EVX2 by OASL expression — BLOOD_Myeloma

Explore this box plot interactively →