OAS3

Across TCGA pan-cancer cohorts, OAS3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated OAS3 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher OAS3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OAS3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where OAS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.908	1.000	.009	36	view →
LUAD	DFS	Median	III,IV	0.967	0.551	.003	17	view →
PDAC	OS	Tertile	IV	0.443	0.973	.024	14	view →
CCRCC	OS	Median	All	0.728	0.944	.004	11	view →
HNSC	OS	Median	All	0.993	0.941	.028	5	view →
UCEC	OS	Quartile	III,IV	1.000	0.420	.045	4	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.525	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OAS3–COAD (DFS)

Open the COAD breakdown →