OAS3

Across TCGA pan-cancer cohorts, OAS3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of OAS3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OAS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OAS3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where OAS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OAS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+1.985	<.001	12	view →
KIRC	Male	IV	+1.289	<.001	12	view →
BLCA	All	III,IV	+1.799	<.001	11	view →
STAD	All	III,IV	+2.278	<.001	8	view →
BRCA	All	III,IV	+1.534	<.001	8	view →
COAD	Male	II,III,IV	+1.504	<.001	8	view →
KIRP	Male	II,III,IV	+1.281	<.001	8	view →
LUAD	All	II,III,IV	+0.867	<.001	8	view →
READ	Male	All	+1.743	<.001	7	view →
KICH	All	All	−0.981	<.001	6	view →
UCEC	All	All	+0.815	.012	4	view →
LIHC	Female	III,IV	+1.055	.008	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

OAS3–HNSC

Open the HNSC breakdown →