OAS3

Across TCGA patient cohorts, OAS3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OAS3-associated genes across cancer lineages are RAD51, Smad4, and c-Met_pY1235. Each is linked with OAS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OAS3-to-partner and partner-to-OAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by OAS3-low versus OAS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAS3→partner) and Y-score (partner→OAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.115	+2.584	.017	.010	3	3
SKCM	Smad4 →	+0.111	+1.597	.010	.040	3	3
SKCM	c-Met_pY1235 →	+0.088	+1.597	.006	.040	3	3
SKCM	Notch1 →	+0.300	+2.597	<.001	.005	3	2
UCEC	Annexin-1 →	+0.531	+2.242	.003	.005	3	2
SKCM	XBP1 →	-0.278	-3.169	.002	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

RAD51 by OAS3 expression — UCEC

Explore this box plot interactively →