OAS3

Across TCGA cell cohorts, OAS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,462 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible OAS3-associated GO terms across cancer lineages are Negative regulation of IP-10 production, Negative regulation of chemokine (C-X-C motif) ligand 2 production, and Negative regulation of viral genome replication. Each is linked with OAS3 in more than 18 cancer types. Because this analysis shows association rather than direction, both OAS3-to-partner and partner-to-OAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of IP-10 production grouped by OAS3-low versus OAS3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OAS3→partner) and Y-score (partner→OAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of IP-10 production →	+1.554	+1.940	<.001	<.001	3	19
LIVER	Negative regulation of chemokine (C-X-C motif) ligand 2 production →	+0.956	+2.020	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.192	+1.935	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Antiviral innate immune response →	+0.097	+2.234	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.090	+1.864	<.001	<.001	3	17
BREAST	Regulation of IP-10 production →	+0.298	+1.701	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,462 associations by consensus.

Negative regulation of IP-10 production by OAS3 expression — LIVER

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