OAS3

Across TCGA cell cohorts, OAS3 mutation is significantly associated with the RNA expression of many other genes, with 682 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OAS3-associated genes across cancer lineages are NEUROD4, PNLIPRP1, and GCAT. Each is linked with OAS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OAS3-to-partner and partner-to-OAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROD4 grouped by OAS3-low versus OAS3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAS3→partner) and Y-score (partner→OAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NEUROD4 →	+0.006	+4.807	<.001	.006	3	2
CNS	PNLIPRP1 →	+0.293	+4.321	<.001	.009	3	2
LARGE_INTESTINE	GCAT →	+1.212	+2.502	.001	.005	3	1
LARGE_INTESTINE	ANKRD54 →	+0.549	+3.237	<.001	.003	3	1
LARGE_INTESTINE	EIF3L →	+0.464	+3.087	.006	.006	3	1
LARGE_INTESTINE	DEPDC5 →	+0.541	+3.459	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 682 associations by consensus.

NEUROD4 by OAS3 expression — BLOOD_Myeloma

Explore this box plot interactively →