OAS3

Across TCGA cell cohorts, OAS3 mutation is significantly associated with the mutation status of many other genes, with 6,210 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OAS3-associated genes across cancer lineages are DNAH6, DNAH8, and KIF2B. Each is linked with OAS3 in more than 4 cancer types. Because this analysis shows association rather than direction, both OAS3-to-partner and partner-to-OAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAH6 grouped by OAS3-low versus OAS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAS3→partner) and Y-score (partner→OAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNAH6 →	+1.925	+3.000	<.001	<.001	1	5
BONE	DNAH8 →	+5.437	+5.437	.003	.003	1	4
SKIN	KIF2B →	+3.094	+4.850	<.001	<.001	1	4
OVARY	NUTM1 →	+3.345	+3.345	.007	.007	1	4
CNS	TRPM2 →	+4.199	+5.347	<.001	<.001	1	4
LARGE_INTESTINE	DSE →	+2.411	+2.129	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,210 associations by consensus.

DNAH6 by OAS3 expression — LARGE_INTESTINE

Explore this box plot interactively →