OAS1

Across TCGA patient cohorts, OAS1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OAS1-associated genes across cancer lineages are Notch1, p70-S6K_pT389, and CDK1. Each is linked with OAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OAS1-to-partner and partner-to-OAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by OAS1-low versus OAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAS1→partner) and Y-score (partner→OAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.174	+2.125	.001	.010	3	2
UCEC	p70-S6K_pT389 →	-0.155	-2.321	.037	.033	3	2
SKCM	CDK1 →	+0.228	+3.000	.008	.035	3	2
UCEC	EGFR_pY1068 →	-0.258	-2.502	.008	.002	3	1
UCEC	eIF4E →	+0.168	+2.700	.042	.006	3	1
UCEC	ERK2 →	+0.208	+3.169	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Notch1 by OAS1 expression — UCEC

Explore this box plot interactively →