OAS1

Across TCGA pan-cancer cohorts, OAS1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated OAS1 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher OAS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated OAS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

BLCA, SKCM, and ACC are the cancer types where OAS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.769	0.646	<.001	121	view →
SKCM	OS	Median	All	0.411	0.267	<.001	79	view →
ACC	OS	Tertile	III,IV	0.316	0.855	<.001	71	view →
UCEC	DFS	Tertile	All	0.634	0.802	.001	56	view →
PAAD	OS	Quartile	All	0.248	0.584	<.001	54	view →
CHOL	DFS	Median	II,III,IV	0.704	0.108	.001	48	view →
LGG	OS	Median	All	0.362	0.529	<.001	48	view →
UVM	DFS	Tertile	All	0.295	0.706	.002	45	view →
THYM	DFS	Quartile	All	0.605	0.930	<.001	42	view →
LUAD	OS	Quartile	All	0.272	0.432	.001	42	view →
LAML	DFS	Tertile	All	0.333	0.758	<.001	36	view →
HNSC	OS	Quartile	IV	0.583	0.907	.002	33	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

OAS1–BLCA (OS)

Open the BLCA breakdown →