OAS1

Across TCGA cell cohorts, OAS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,603 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible OAS1-associated GO terms across cancer lineages are Negative regulation of IP-10 production, Negative regulation of chemokine (C-X-C motif) ligand 2 production, and Regulation of IP-10 production. Each is linked with OAS1 in more than 19 cancer types. Because this analysis shows association rather than direction, both OAS1-to-partner and partner-to-OAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of IP-10 production grouped by OAS1-low versus OAS1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OAS1→partner) and Y-score (partner→OAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of IP-10 production →	+1.639	+3.344	<.001	<.001	3	20
LIVER	Negative regulation of chemokine (C-X-C motif) ligand 2 production →	+1.013	+3.189	<.001	<.001	3	20
BREAST	Regulation of IP-10 production →	+0.295	+2.328	<.001	<.001	3	18
CNS	Type I interferon-mediated signaling pathway →	+0.175	+3.223	<.001	<.001	3	17
STOMACH	Interferon-mediated signaling pathway →	+0.156	+3.617	<.001	<.001	3	16
OESOPHAGUS	Intracellular receptor signaling pathway →	+0.073	+4.026	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,603 associations by consensus.

Negative regulation of IP-10 production by OAS1 expression — LIVER

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