OAS1

Across TCGA cell cohorts, OAS1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OAS1-associated genes across cancer lineages are BANF2, GJA10, and TEX55. Each is linked with OAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OAS1-to-partner and partner-to-OAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BANF2 grouped by OAS1-low versus OAS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAS1→partner) and Y-score (partner→OAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BANF2 →	+0.216	+3.793	.002	.007	3	1
LARGE_INTESTINE	GJA10 →	+0.069	+4.217	<.001	.001	3	1
LARGE_INTESTINE	TEX55 →	+0.015	+3.684	.002	.006	3	1
LARGE_INTESTINE	MS4A10 →	+0.015	+3.684	<.001	.006	3	1
LARGE_INTESTINE	HSF5 →	+0.061	+4.000	<.001	.004	3	1
LARGE_INTESTINE	GDF3 →	+0.047	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

BANF2 by OAS1 expression — LARGE_INTESTINE

Explore this box plot interactively →