NXT1-AS1

Across TCGA pan-cancer cohorts, NXT1-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NXT1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NXT1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NXT1-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where NXT1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NXT1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.221	<.001	12	view →
COAD	Female	All	+0.437	<.001	9	view →
BLCA	Male	All	+0.377	<.001	8	view →
THCA	Female	All	−0.144	<.001	6	view →
CHOL	All	All	+0.325	<.001	5	view →
BRCA	All	II,III,IV	+0.079	.007	4	view →
LUSC	Male	All	+0.195	<.001	3	view →
LIHC	All	All	+0.038	.013	3	view →
UCEC	All	IV	+0.505	.040	2	view →
READ	All	All	+0.302	.016	2	view →
ESCA	All	All	+0.218	.007	2	view →
STAD	Male	All	+0.115	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NXT1-AS1–HNSC

Open the HNSC breakdown →