NXPE1

Across TCGA cell cohorts, NXPE1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NXPE1-associated genes across cancer lineages are ZNF366, LRRC31, and CT45A6. Each is linked with NXPE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPE1-to-partner and partner-to-NXPE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF366 grouped by NXPE1-low versus NXPE1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPE1→partner) and Y-score (partner→NXPE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF366 →	+0.013	+4.906	<.001	.006	3	1
SKIN	LRRC31 →	+0.031	+4.415	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	CT45A6 →	+0.060	+5.357	<.001	.003	3	1
LARGE_INTESTINE	MS4A4A →	+0.219	+3.678	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.329	+4.688	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ZNF366 by NXPE1 expression — OESOPHAGUS

Explore this box plot interactively →