NXPE1

Across TCGA pan-cancer cohorts, NXPE1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated NXPE1 data layer compared with 5 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher NXPE1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NXPE1 expression acts as an unfavorable survival marker, although some lineages such as READ and GBM show a favorable association.

BRCA, DLBC, and UVM are the cancer types where NXPE1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
DLBC	DFS	Quartile	II,III,IV	0.143	0.871	.012	31	view →
UVM	OS	Tertile	III,IV	0.070	0.843	<.001	21	view →
READ	DFS	Quartile	II,III,IV	0.931	0.429	.005	20	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
LGG	OS	Quartile	All	0.739	0.926	.008	13	view →
GBM	OS	Tertile	All	0.501	0.333	.018	12	view →
LIHC	DFS	Tertile	All	0.266	0.459	.023	12	view →
COAD	DFS	Tertile	All	0.764	0.630	.021	8	view →
STAD	DFS	Tertile	III,IV	0.292	0.637	.048	6	view →
SCLC	DFS	Median	IV	0.158	0.542	.030	6	view →
TGCT	OS	Quartile	All	0.937	1.000	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

NXPE1–BRCA (DFS)

Open the BRCA breakdown →