NXN

Across TCGA pan-cancer cohorts, NXN mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NXN data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher NXN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NXN expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

OV, HNSC, and LUAD are the cancer types where NXN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	All	0.516	0.819	.038	16	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.884	.011	12	view →
LUAD	DFS	Tertile	III,IV	0.959	0.507	.005	12	view →
LSCC	DFS	Tertile	All	0.374	0.870	.010	6	view →
PDAC	DFS	Tertile	IV	0.221	0.777	.024	3	view →
CCRCC	DFS	Tertile	All	0.546	0.920	.006	2	view →
UCEC	OS	Tertile	All	0.873	1.000	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NXN–OV (DFS)

Open the OV breakdown →