NXN

Across TCGA pan-cancer cohorts, NXN RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NXN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NXN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NXN is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, KICH, and THCA are the cancer types where NXN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NXN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.296	<.001	12	view →
KICH	Female	All	−2.322	<.001	8	view →
THCA	Male	All	+1.184	<.001	8	view →
KIRP	Female	All	+1.304	.020	4	view →
LUAD	Female	All	−0.778	<.001	4	view →
BLCA	All	III,IV	−0.775	.015	4	view →
CHOL	Female	All	+3.476	<.001	3	view →
LIHC	All	III,IV	−0.856	.003	3	view →
READ	Female	All	−2.137	.010	2	view →
UCEC	All	All	−0.628	.008	2	view →
BRCA	All	All	−0.217	.046	2	view →
KIRC	Male	II,III,IV	−0.436	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NXN–HNSC

Open the HNSC breakdown →