NXF5

Across TCGA pan-cancer cohorts, NXF5 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated NXF5 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NXF5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NXF5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

LUAD, UCEC, and OV are the cancer types where NXF5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.138	0.669	<.001	38	view →
UCEC	DFS	Median	All	0.941	0.609	.007	32	view →
OV	OS	Median	II,III,IV	0.308	0.691	.033	18	view →
READ	DFS	Median	II,III,IV	0.083	0.830	<.001	18	view →
LGG	OS	Median	All	0.101	0.909	<.001	12	view →
COAD	OS	Median	III,IV	0.140	0.792	<.001	12	view →
BRCA	DFS	Median	All	0.754	0.950	<.001	6	view →
LUSC	DFS	Median	II,III,IV	0.202	0.672	.024	3	view →
SKCM	OS	Median	III,IV	1.000	0.780	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

NXF5–LUAD (OS)

Open the LUAD breakdown →