NWD2

Across TCGA patient cohorts, NWD2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NWD2-associated genes across cancer lineages are eIF4E, ERK2, and MEK1. Each is linked with NWD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NWD2-to-partner and partner-to-NWD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NWD2-low versus NWD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NWD2→partner) and Y-score (partner→NWD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.141	+2.920	.019	<.001	3	2
UCEC	ERK2 →	+0.175	+1.807	.001	.003	3	2
UCEC	MEK1 →	+0.402	+3.247	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.673	+1.954	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.269	+2.169	.021	.003	3	2
UCEC	ATM →	-0.409	-2.156	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

eIF4E by NWD2 expression — UCEC

Explore this box plot interactively →