NWD2

Across TCGA pan-cancer cohorts, NWD2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated NWD2 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NWD2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NWD2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LGG show a favorable association.

STAD, BRCA, and ACC are the cancer types where NWD2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	All	0.344	0.774	<.001	39	view →
BRCA	OS	Quartile	III,IV	0.791	0.455	<.001	32	view →
ACC	OS	Quartile	III,IV	0.293	0.731	<.001	31	view →
UVM	DFS	Tertile	All	0.413	0.869	.002	27	view →
LGG	DFS	Quartile	All	0.915	0.771	<.001	26	view →
KIRP	DFS	Tertile	IV	0.095	0.577	.010	25	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
LUAD	DFS	Tertile	IV	0.301	0.774	.019	12	view →
UCEC	DFS	Median	All	0.579	0.698	.001	12	view →
BLCA	DFS	Tertile	All	0.695	0.463	.017	11	view →
ESCA	OS	Median	All	0.409	0.584	.027	8	view →
PAAD	DFS	Quartile	II,III,IV	0.594	0.316	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

NWD2–STAD (OS)

Open the STAD breakdown →