NUP98

Across TCGA pan-cancer cohorts, NUP98 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUP98 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NUP98 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NUP98 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, BLCA, and CESC are the cancer types where NUP98 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.940	0.608	.002	30	view →
BLCA	DFS	Median	IV	0.115	0.483	<.001	23	view →
CESC	OS	Median	IV	0.121	0.591	.029	12	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUP98–UCEC (DFS)

Open the UCEC breakdown →