NUP98

Across TCGA pan-cancer cohorts, NUP98 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NUP98 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUP98 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUP98 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where NUP98 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.886	1.000	.002	52	view →
PDAC	OS	Quartile	II,III,IV	0.345	0.619	<.001	24	view →
LSCC	OS	Median	All	0.895	0.729	.004	21	view →
COAD	DFS	Median	II,III,IV	1.000	0.895	.045	18	view →
HNSC	OS	Median	All	0.778	0.913	.005	15	view →
LUAD	DFS	Median	III,IV	0.716	0.332	.011	15	view →
OV	DFS	Median	All	1.000	0.824	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NUP98–CCRCC (OS)

Open the CCRCC breakdown →