NUP98

Across TCGA patient cohorts, NUP98 mutation is significantly associated with the RNA expression of many other genes, with 7,566 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP98-associated genes across cancer lineages are FCER1A, PTMAP4, and ZWINT. Each is linked with NUP98 in more than 4 cancer types. Because this analysis shows association rather than direction, both NUP98-to-partner and partner-to-NUP98 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCER1A grouped by NUP98-low versus NUP98-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP98→partner) and Y-score (partner→NUP98) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FCER1A →	-0.915	-2.646	.001	<.001	3	5
COAD	PTMAP4 →	+1.504	+2.727	<.001	.003	3	5
UCEC	ZWINT →	+0.797	+2.104	<.001	<.001	3	5
UCEC	HAUS1 →	+0.540	+1.510	<.001	<.001	3	4
UCEC	BUB3 →	+0.513	+1.621	<.001	<.001	3	4
SKCM	FGD5 →	-0.538	-2.971	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,566 associations by consensus.

FCER1A by NUP98 expression — STAD

Explore this box plot interactively →