NUP98

Across TCGA patient cohorts, NUP98 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP98-associated genes across cancer lineages are PKC-delta_pS664, Rictor_pT1135, and Cyclin-B1. Each is linked with NUP98 in more than 2 cancer types. Because this analysis shows association rather than direction, both NUP98-to-partner and partner-to-NUP98 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by NUP98-low versus NUP98-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP98→partner) and Y-score (partner→NUP98) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PKC-delta_pS664 →	-0.130	-3.321	.006	.008	3	3
STAD	Rictor_pT1135 →	-0.148	-2.305	.006	.032	3	3
UCEC	Cyclin-B1 →	+0.675	+1.750	<.001	<.001	3	3
UCEC	S6_pS240_S244 →	+0.282	+1.428	.008	.025	3	3
BLCA	S6 →	-0.470	-2.321	.007	.033	3	2
BLCA	cIAP →	-0.100	-1.807	.044	.026	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

PKC-delta_pS664 by NUP98 expression — STAD

Explore this box plot interactively →