NUP98

Across TCGA cell cohorts, NUP98 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,355 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NUP98-associated GO terms across cancer lineages are Telomere localization, Telomere tethering at nuclear periphery, and Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Each is linked with NUP98 in more than 19 cancer types. Because this analysis shows association rather than direction, both NUP98-to-partner and partner-to-NUP98 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere localization grouped by NUP98-low versus NUP98-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP98→partner) and Y-score (partner→NUP98) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Telomere localization →	+0.217	+0.752	.004	<.001	3	20
URINARY_TRACT	Telomere tethering at nuclear periphery →	+0.166	+0.934	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.111	+1.076	.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.083	+0.799	<.001	<.001	3	16
BLOOD_Myeloma	Positive regulation of mRNA splicing, via spliceosome →	+0.136	+1.057	<.001	<.001	3	16
BONE	Centrosome duplication →	+0.129	+0.573	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,355 associations by consensus.

Telomere localization by NUP98 expression — LIVER

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