NUP88

Across TCGA patient cohorts, NUP88 mutation is significantly associated with the RNA expression of many other genes, with 1,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP88-associated genes across cancer lineages are DEFB103A, PINCR, and RSL24D1P4. Each is linked with NUP88 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP88-to-partner and partner-to-NUP88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB103A grouped by NUP88-low versus NUP88-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP88→partner) and Y-score (partner→NUP88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	DEFB103A →	+0.094	+7.977	<.001	.007	3	2
COAD	PINCR →	+0.370	+3.383	<.001	.002	3	2
BLCA	RSL24D1P4 →	+0.053	+5.307	<.001	.001	3	2
UCEC	MTHFD1 →	+0.534	+2.928	<.001	<.001	3	2
UCEC	OIP5 →	+0.755	+3.000	<.001	<.001	3	2
UCEC	R3HCC1 →	+0.400	+2.914	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,712 associations by consensus.

DEFB103A by NUP88 expression — LGG

Explore this box plot interactively →