NUP58

Across TCGA pan-cancer cohorts, NUP58 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUP58 data layer compared with 27 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NUP58 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUP58 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where NUP58 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.330	0.718	<.001	70	view →
LUAD	DFS	Tertile	II,III,IV	0.994	0.738	.002	35	view →
HNSC	DFS	Tertile	III,IV	0.647	0.903	.005	15	view →
OV	DFS	Tertile	All	1.000	0.548	.039	4	view →
LSCC	DFS	Median	II,III,IV	0.851	0.535	.009	3	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.849	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUP58–PDAC (DFS)

Open the PDAC breakdown →