NUP58

Across TCGA pan-cancer cohorts, NUP58 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NUP58’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NUP58 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NUP58 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where NUP58 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUP58 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.857	<.001	12	view →
KIRC	Female	All	+0.643	<.001	11	view →
COAD	Male	All	+1.080	<.001	10	view →
BLCA	Male	III,IV	+1.045	<.001	10	view →
THCA	Female	II,III,IV	−0.806	<.001	9	view →
STAD	Male	II,III,IV	+1.161	<.001	8	view →
KICH	Female	II,III,IV	−1.367	<.001	7	view →
READ	All	III,IV	+1.255	<.001	7	view →
LIHC	All	All	+0.421	<.001	7	view →
BRCA	All	II,III,IV	+0.481	<.001	6	view →
CHOL	All	All	+1.430	<.001	4	view →
ESCA	All	All	+1.164	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NUP58–HNSC

Open the HNSC breakdown →