NUP58

Across TCGA patient cohorts, NUP58 protein abundance is significantly associated with the RNA expression of many other genes, with 10,524 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NUP58-associated genes across cancer lineages are ZNF831, ACSM5, and LINC01480. Each is linked with NUP58 in more than 3 cancer types. Because this analysis shows association rather than direction, both NUP58-to-partner and partner-to-NUP58 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NUP58 versus ZNF831 in LSCC, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP58→partner) and Y-score (partner→NUP58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF831 →	-0.564	-0.104	<.001	<.001	3	4
GBM	ACSM5 →	-0.930	-0.214	<.001	.002	3	4
GBM	LINC01480 →	-0.896	-0.211	<.001	<.001	3	4
HNSC	LSM12 →	+0.677	+0.116	.003	.005	3	4
COAD	PRKACB →	-1.040	-0.187	<.001	<.001	3	4
BRCA	TXNDC15 →	-0.500	-0.152	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,524 associations by consensus.

NUP58 vs ZNF831 — LSCC

Explore this scatter interactively →